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CRISPR gene editing in human embryos wreaks chromosomal mayhem

Editing of Human Embryos Is Controversial, by Pascal Goetgheluck/ Science Photo Library
Editing of Human Embryos Is Controversial, by Pascal Goetgheluck/ Science Photo Library
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Excerpt: A suite of experiments that use the gene-editing tool CRISPR-Cas9 to modify human embryos has revealed how the process can make large, unwanted changes to the genome at or near the target site.

Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.

A suite of experiments that use the gene-editing tool CRISPR-Cas9 to modify human embryos has revealed how the process can make large, unwanted changes to the genome at or near the target site.

The studies were published this month on the preprint server bioRxiv, and have not yet been peer-reviewed. But taken together, they give scientists a good look at what some say is an underappreciated risk of CRISPR-Cas9 editing. Previous experiments have revealed that the tool can make ‘off-target’ gene mutations far from the target site, but the nearby changes identified in the latest studies can be missed by standard assessment methods.

“The on-target effects are more important and would be much more difficult to eliminate,” says Gaétan Burgio, a geneticist at the Australian National University in Canberra.

Nature, Published online: 25 June 2020; doi:10.1038/d41586-020-01906-4

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chroniclesofcarlos

chroniclesofcarlos

Are Bigfoot real? Yes, they are! I investigate, create, and share mainstream educational content, Bigfoot and related phenomena, and the scientific methods and principles that corroborate our stories. I have lived and traveled all over North America, Europe, and Africa, have had encounters with Bigfoot and UFOs in North America, and have even had an NDE in Africa. Education: BA and MA in Biological Anthropology Languages: English and Spanish Career: Certified Coach and Teacher, Licensed Entrepreneur Passions: coaching, mentoring, learning, teaching, coaching; the sciences, and cryptozoology Subjects: The Sciences, Cryptozoology

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Are Bigfoot real? Yes, they are!

I investigate, create, and share mainstream educational content, Bigfoot encounters and other mysteries, mythologies, and legends of the unknown, and the scientific methods and principles that corroborate our stories.

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